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Obesity Hub

Transdisciplinary approaches for precision research and treatment

Overview

The Obesity Hub is a collaborative effort that brings together a diverse team of 27 faculty members from 16 different departments, spanning six schools and five centers and institutes. The primary focus of this initiative is to unravel the complexities behind why individuals with similar diets and exercise regimens can have drastically different susceptibilities to weight gain. By moving beyond the traditional "one-size-fits-all" treatment models, the project aims to pioneer precision approaches to obesity care.

Specific Aims

The project is built around three core objectives:

  1. Parallel Mouse and Human Studies: Investigate whether genomic, metabolomic, and microbial factors contribute to the diverse responses in weight gain and weight loss among individuals.
  2. Precision Obesity Pilot: Implement a specialized obesity treatment pilot in a UNC clinic. This will involve minute-by-minute monitoring of glucose levels, diet, and physical activity, laying the groundwork for future precision obesity care at Carolina.
  3. DATA TRANSLATOR App: Develop an application that serves as a platform for precision obesity science and treatment. This app will integrate genetic, metabolomic, and dietary data, offering a holistic view of an individual's health.

By leveraging a transdisciplinary approach and focusing on precision treatments, the Obesity Hub aims to advance our understanding of obesity and bring about more effective, individualized care solutions.

For more in-depth information about the Obesity Hub, you can read the feature on Spotlight Carolina: Penny Gordon-Larsen or visit UNC's Creativity Hubs Winners 2018 page.

Team and Collaboration

The Obesity Hub is a collective endeavor that harnesses the expertise of faculty from various disciplines. The project facilitates robust partnerships across different departments, schools, and centers, aiming for a transdisciplinary approach to obesity research and treatment. Below is the Obesity Hub team:

researcher
role
school
department
Ana Bardone-Cone
Co-I
College
Psychology
Annie Green Howard
Co-I
SPH
Biostatistics
Christy Avery
Co-I
SPH
Epidemiology
Craig Lee
Co-I
Pharmacy
Pharmacotherapy
Deb Tate
Co-I/Steering
SPH & SOM
Nutrition/Health Behavior
Diane Berry
Co-I
Nursing
Nursing
Elizabeth Frankenberg
Advisory
CPC
Sociology
Ethan Basch
Advisory
Lineberger
Hematology
Ian Carroll
Co-I
SPH & SOM
Nutrition
Jennifer Leeman
Co-I
Nursing
Nursing
John Buse
Advisory
NC TraCS
Endocrinology
John French
Co-I
NRI
Nutrition
Kari North
Co-I/Steering
SPH
Epidemiology
Katie Meyer
Co-I
SPH & SOM/NRI
Nutrition
Kimon Divaris
Co-I
Dentistry
Pediatric Dentistry
Leslie Lytle
Co-I
SPH
Health Behavior
Michael Kosorok
Advisory
SPH
Biostatistics
Penny Gordon-Larsen
PI/Steering
SPH
Nutrition
Rebecca Fry
Co-I
SPH
Environmental Sciences & Engineering
Sally Stearns
Co-I
SPH
Health Policy Management
Sriram Machineni
Co-I/Steering
SOM
Endocrinology
Stan Ahalt
Co-I
RENCI
Computer Science
Steve Hursting
Co-I
SPH & SOM/NRI
Nutrition
Steve Zeisel
Co-I/Steering
SPH & SOM/NRI
Nutrition
Susan Sumner
Co-I
SPH & SOM/NRI
Nutrition
Sylvana Barros
Co-I
Dentistry
Periodontology
Tim Wiltshire
Co-I
Pharmacy
Pharmacogenomics
Vicki Bautch
Co-I/Steering
College
Biology
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